![]() The fluoroquinolones also possess activity against bacteria in the stationary phase by an alteration of the permeability of the outer membrane phospholipid cell wall. Resealing of the double standard helix is inhibited resulting in irreversible degradation of the chromosomal DNA. The mechanism of action of the quinolones is unique among antimicrobials – they act primarily to inhibit bacterial DNA gyrase, an enzyme responsible for controlling the supercoiling of bacterial DNA during replication. ATC Vet Code: QJ01MA90.Įnrofloxacin is bactericidal in action with activity against Gram positive and Gram negative bacteria and mycoplasmas. At 50 mg/kg given once daily for 21 consecutive days, blindness can occur.ĭogs: In dogs enrofloxacin may affect articular cartilage during the period of rapid growth.Įnrofloxacin is a synthetic, broad spectrum antimicrobial substance, belonging to the fluoroquinolone group of antibiotics. Doses of 30 mg/kg given once daily for 21 consecutive days have been shown to cause irreversible ocular damage. In target animal studies, cats have been shown to suffer ocular damage after receiving doses of more than 15 mg/kg once daily for 21 consecutive days. There is no antidote and treatment should be symptomatic.Ĭats: Retinotopic effects including blindness can occur when the recommended dose is exceeded. In accidental overdose, vomiting, diarrhoea, and CNS/behavioural changes may occur. Not recommended for use in cats less than 8 weeks of age.ĭo not exceed the recommended dose. Not for use in dogs less than 1 year of age or in exceptionally large breeds of dog with a longer growth period under 18 months of age, as articular cartilage may be affected during the period of rapid growth. The product may be used safely in pregnant and lactating animals.īaytril Flavour Tablets should not be used for prophylaxis. Large dogs: 1 tablet Baytril Flavour Tablets 150 mg per 30 kg bodyweight Medium dogs: 1 tablet Baytril Flavour Tablets 50 mg per 10 kg bodyweight Treatment may be initiated with Baytril 5% Injection or Baytril 2.5% Injection and maintained with Baytril Flavour Tablets.Ĭats and small dogs: 1 Baytril Flavour Tablet 15 mg per 3 kg bodyweight ![]() The dosage rate of enrofloxacin is 5 mg/kg given orally once daily or as a divided dose twice daily for 3 to 10 days with or without food.
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